Properties are selected based on real traveler reviews and popularity among guests who’ve booked a night in Florence on Hotels.com. These Florence hotels consistently deliver on comfort, location and traveler experience. Last updated on .
Hotels in Florence
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Where to stay in Florence?

Howard Johnson by Wyndham Florence
Howard Johnson by Wyndham FlorenceFlorence
8.6 out of 10, Excellent, (2,677 reviews)
$68 nightly
The price is $76
Jun 25 - Jun 26
Total with taxes and fees

Park Inn by Radisson Florence, SC
Park Inn by Radisson Florence, SCFlorence
9.0 out of 10, Wonderful, (2,323 reviews)
$89 nightly
The price is $100
Jun 28 - Jun 29
Total with taxes and fees

Hyatt Place Florence Downtown
Hyatt Place Florence DowntownFlorence
9.0 out of 10, Wonderful, (1,000 reviews)
$114 nightly
The price is $128
Jul 1 - Jul 2
Total with taxes and fees

Comfort Inn & Suites Florence Center Area
Comfort Inn & Suites Florence Center AreaFlorence
9.0 out of 10, Wonderful, (1,308 reviews)
$101 nightly
The price is $113
Jul 19 - Jul 20
Total with taxes and fees

La Quinta Inn & Suites by Wyndham Florence
La Quinta Inn & Suites by Wyndham FlorenceFlorence
7.8 out of 10, Good, (1,576 reviews)
$86 nightly
The price is $97
Jun 29 - Jun 30
Total with taxes and fees

Hotel Florence, Tapestry Collection by Hilton
Hotel Florence, Tapestry Collection by HiltonFlorence
8.8 out of 10, Excellent, (643 reviews)
$125 nightly
The price is $139
Jul 20 - Jul 21
Total with taxes and fees

Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHG
Holiday Inn Express & Suites Florence I-95 & I-20 Civic Ctr by IHGFlorence
9.2 out of 10, Wonderful, (1,001 reviews)
$118 nightly
The price is $132
Jun 28 - Jun 29
Total with taxes and fees

Staybridge Suites Florence - Civic Center by IHG
Staybridge Suites Florence - Civic Center by IHGFlorence
9.4 out of 10, Exceptional, (1,000 reviews)
$139 nightly
The price is $156
Jul 19 - Jul 20
Total with taxes and fees

Quality Inn & Suites Florence Civic Center
Quality Inn & Suites Florence Civic CenterFlorence
8.6 out of 10, Excellent, (206 reviews)
$89 nightly
The price is $100
Jun 25 - Jun 26
Total with taxes and fees

Home2 Suites by Hilton Florence, SC
Home2 Suites by Hilton Florence, SCFlorence
8.4 out of 10, Very Good, (1,004 reviews)
$134 nightly
The price is $150
Jun 28 - Jun 29
Total with taxes and fees

Residence Inn Marriott Florence
Residence Inn Marriott FlorenceFlorence
8.8 out of 10, Excellent, (559 reviews)
$122 nightly
The price is $137
Jun 29 - Jun 30
Total with taxes and fees

TownePlace Suites by Marriott Florence
TownePlace Suites by Marriott FlorenceFlorence
9.0 out of 10, Wonderful, (834 reviews)
$118 nightly
The price is $132
Jun 28 - Jun 29
Total with taxes and fees

SpringHill Suites by Marriott Florence
SpringHill Suites by Marriott FlorenceFlorence
8.4 out of 10, Very Good, (1,002 reviews)
$105 nightly
The price is $117
Jul 6 - Jul 7
Total with taxes and fees

Hampton Inn & Suites Florence Center
Hampton Inn & Suites Florence CenterFlorence
9.0 out of 10, Wonderful, (908 reviews)
$111 nightly
The price is $124
Jul 5 - Jul 6
Total with taxes and fees

Hampton Inn & Suites Florence-North-I-95
Hampton Inn & Suites Florence-North-I-95Florence
9.0 out of 10, Wonderful, (938 reviews)
$118 nightly
The price is $132
Jul 1 - Jul 2
Total with taxes and fees

Fairfield Inn & Suites by Marriott Florence I-20
Fairfield Inn & Suites by Marriott Florence I-20Florence
9.0 out of 10, Wonderful, (642 reviews)
$118 nightly
The price is $132
Jun 28 - Jun 29
Total with taxes and fees

Tru by Hilton Florence I-95
Tru by Hilton Florence I-95Florence
8.6 out of 10, Excellent, (1,000 reviews)
$109 nightly
The price is $122
Jul 1 - Jul 2
Total with taxes and fees

Aloft by Marriott Florence
Aloft by Marriott FlorenceFlorence
8.6 out of 10, Excellent, (354 reviews)
$111 nightly
The price is $124
Jun 29 - Jun 30
Total with taxes and fees

Comfort Suites Florence I-95
Comfort Suites Florence I-95Florence
8.2 out of 10, Very Good, (1,001 reviews)
$100 nightly
The price is $111
Jul 20 - Jul 21
Total with taxes and fees

Homewood Suites by Hilton Florence
Homewood Suites by Hilton FlorenceFlorence
8.4 out of 10, Very Good, (701 reviews)
$106 nightly
The price is $119
Jul 7 - Jul 8
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Check out pet-friendly hotels in Florence

9.0 out of 10, Wonderful, (1308)
$101 nightly
The price is $113
Jul 19 - Jul 20
Total with taxes and fees
You may also like hotels with pools in Florence

Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHG
Holiday Inn Express Hotel & Suites Florence I-95 at Hwy 327 by IHGFlorence
8.6 out of 10, Excellent, (1002)
$130 nightly
The price is $146
Jun 28 - Jun 29
Total with taxes and fees
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Go beyond your typical stay in Florence
Pet friendly
Top landmarks in Florence
Florence and related destinations
Between the intersections of two major highways lies a city where history and Southern culture blend seamlessly. The Florence County Museum showcases local heritage, while the War Between the States Museum offers a window into Civil War history. Downtown restaurants serve up authentic Southern cuisine worth the detour off I-95. Catch performances at Francis Marion University's Performing Arts Center, with acoustics rivaling larger cities. Florence Veterans Park provides a peaceful retreat with thoughtful memorials. Shoppers enjoy Magnolia Mall, while families visit Greenwood Baseball Park's playgrounds. The city's railroad heritage remains visible in its layout – a reminder of how this transportation hub became the beating heart of the Pee Dee region.

Check out reviews of Florence hotels guests love

Park Inn by Radisson Florence, SC
10/10 Excellent
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